Evaluation of drug efficacy using central nervous system and neurodegenerative disease models
Scantox, for which we act as an agent, undertakes efficacy evaluation trials of pharmaceuticals using various central nervous system and neurodegenerative disease models. In addition to contract testing, they also maintain a frozen biobank of blood and tissue samples collected from various disease models, and can deliver necessary samples to our clients' facilities.
For inquiries or requests regarding Scantox testing, please feel free to contact Lunapass Toxicology and Pathology Laboratory.
About Scantox
As a contract research organization (CRO), Scantox supports a wide range of drug development activities, from lead compound optimization through in vitro and in vivo efficacy test models, formulation development, regulatory toxicity testing, to drug manufacturing for Phase I and II clinical trials. With our trusted collaboration based on our advanced technical capabilities and over 40 years of scientific experience, we are able to provide a one-stop service for your development projects.
In particular, we are one of the world's leading CROs in the field of pharmaceutical safety testing using miniature pigs, and we also have extensive experience in efficacy testing and genotoxicity testing in the fields of neurological disorders and rare diseases.
Facility Overview
The Scantox Group is headquartered in Ejby, Lille Skensved, approximately 30 minutes from Copenhagen, and has further subsidiaries in Austria, Sweden and the UK.
In vivo efficacy studies:
Disease models (mouse, rat)
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APP Transgenic Mouse Model
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APPSL
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APPSL x hQC
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5xFAD
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Tg2576
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TAU Transgenic Mouse Model
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TMHT
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hTau
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PS19
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scopolamine-administered mice
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Tau seeding mouse model
In vitro efficacy testing:
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Aβ-induced toxicity
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Screening for Aβ peptide formation or secretase inhibitors
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Measurement of Aβ aggregates
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Tau hyperphosphorylation
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In vitro tau agglutination assay
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Tau intake and sowing
Facility Overview
The Scantox Group is headquartered in Ejby, Lille Skensved, approximately 30 minutes from Copenhagen, and has further subsidiaries in Austria, Sweden and the UK.
Scantox A/S
Hestehavevej 36A, Ejby
4623 Lille Skensved
Denmark
Tel: +45 5686 1500
Regulatory Toxicity Studies
General Toxicology Testing (Non-GLP/GLP):
Single-dose toxicity test/Repeated-dose toxicity test
Safety pharmacology studies:
Cardiovascular system (dog, minipig), CNS, respiratory system (rat)
Reproductive and developmental toxicity tests (minipigs, rats, rabbits)
Pharmacokinetic studies
Juvenile animal testing (mini pigs)
SEND
Scantox Neuro
Parkring 12
8074 Grambach, Austria
+43 (0) 316 258111
Preclinical trials for neurodegenerative and rare diseases
In vitro:
Alzheimer's disease model, Parkinson's disease model, neuroinflammation, lesion induction model
In vivo:
Alzheimer's, Parkinson's disease, ALS, Huntington's disease, MS, NPC1, MPS, lipid storage diseases such as Gaucher, Alport syndrome, dyslipidemia, psychosis, anxiety, schizophrenia, autism